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In addition, if the correlation between the covariate and biomarker is high in disease group and if AUC is approximately 0.75, then there is significant difference between adjusted AUC and AUC.
PSA (Prostate Specific Antigen), a biomarker used for prostate cancer diagnosis, was analyzed based on the adjustments by age. Matching in studies of classification accuracy: implications for analysis, efficiency, and assessment of incremental value.
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Adjusting for covariates in studies of diagnostic, screening, or prognostic markers: an old concept in a new setting. Model does not work well when sample size of disease and healthy are less than 50. Adjusting for Covariate Effects in Biomarker Studies Using The Subject-Specific Threshold ROC Curve.