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22-Jan-2020 12:51

FTD is a common early-onset dementia (occurring in patients aged The symptoms of bv FTD include progressive personality and behavioral changes, apathy, and disinhibition in interpersonal interactions.

Thus, discriminating the behavioral features of bv FTD from those of primary psychiatric disorders such as depression, schizophrenia, bipolar disorder, and borderline personality disorder may be challenging (16, 17).Language dysfunction is the main symptom during the first 2 years of PPA.Deficits in object naming, syntax, or word comprehension may become apparent during conversation or may be identified using speech and language assessment.In this paper, the pathophysiology underlying FTD, which is characterized by the selective degeneration of the frontal and temporal cortices, is reviewed.

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We also discuss recent advancements in FTD research from the perspectives of clinical, imaging, molecular characterizations, and treatment.

Up to 15% of patients with FTD have concomitant MND, and nearly 30% of patients present with mild features of MND (9, 22).



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