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It had nothing to do with those bloody eyes that everyone's going on about all the time." In 2002, Murphy starred as Adam in a theatre production of Neil La Bute's The Shape of Things at the Gate Theatre in Dublin.He was cast in the lead role in Danny Boyle's horror film 28 Days Later (2002).He portrayed a deserting soldier who shares a grim scene with Jude Law's character, and was only on location in Romania for a week.Murphy stated that it was a "massive production", remarking that director Anthony Minghella was the calmest director he'd ever met.He is closely associated with the work of Professor Pat Dolan, Director UCFRC and UNESCO Chair in Children, Youth and Civic Engagement.In the early 2010s, he appeared in the films In Time (2011), Retreat (2011) and Red Lights (2012).
Reflecting on his roles in 28 Days Later and the "sad-sack Dublin shelf-stacker" in Intermission, Sarah Lyall of the International Herald Tribune stated that Murphy brought "fluent ease to the roles he takes on, a graceful and wholly believable intensity.
He was raised Roman Catholic, and attended the Catholic secondary school Presentation Brothers College; there he did well academically but got into trouble often, sometimes being suspended, until he decided in his fourth year that misbehaving was not worth the hassle.